<div class="text">
  <span class="row">
    <span class="col">
      <span class="word">word1</span>
    </span>
    <span class="col">
      <span class="word">word2</span>
      <span class="word">word3</span>
    </span>
    <span class="col">
      <span class="word">word4</span>
    </span>    
  </span>
</div>

.text .row {
  display:flex;  
  flex-direction:row;
  align-items:center;
}

.text .row .col {
  display:flex;
  flex-direction:column;
}

.text .word {
  font-size:24px;
  padding-right:20px;
}