<div>
  <span class="one"></span>
  <span class="two"></span>
  <span class="three"></span>
  <span class="four"></span>
 </div>

body {
  margin: 0;
  background: #F4EDE5;
}
div {
  width: 100px;
  height: 100px;
  transform: translate(-50%, -50%);
  position: absolute; 
  top: 50%; 
  left: 50%;
}
span {
  display: block;
  position: absolute;
  width: 40%;
  height: 40%;
  border-radius: 50%;
  box-shadow: 2px 2px 3px rgba(0,0,0,.4);
  -webkit-animation: run 2s infinite ease-in-out;
  animation: run 2s infinite ease-in-out;
}

.one {
  background: #F3B222;
  -webkit-animation-delay: 1.5s;
  animation-delay: 1.5s;
}
.two {
  background: #F0653E;
  -webkit-animation-delay: 1s;
  animation-delay: 1s;
}
.three {
  background: #B9C0C0;
  -webkit-animation-delay: 0.5s;
  animation-delay: 0.5s;
}
.four {
  background: #8F7473;
}

@-webkit-keyframes run {
  0% {
    transform: translate(0%);
    border-radius: 50%;
  }
  25% {
    transform: translate(150%) scale(0.5); 
    border-radius: 0%;
  }
  50% {
    transform: translate(150%, 150%);
    border-radius: 50%; 
  }
  75% {
    transform: translate(0%, 150%) scale(0.5); 
    border-radius: 0%;
  }
}
@keyframes run {
  0% {
    transform: translate(0%);
    border-radius: 50%;
  }
  25% {
    transform: translate(150%) scale(0.5); 
    border-radius: 0%;
  }
  50% {
    transform: translate(150%, 150%);
    border-radius: 50%; 
  }
  75% {
    transform: translate(0%, 150%) scale(0.5); 
    border-radius: 0%;
  }
}