<div class="map">
  
  <div class="map-item map-item1">
    <a class="marker marker1" href="#marker1">1</a>

    <aside id="marker1" class="map-popup">
      <h3 class="popup-title">Popup Title</h3>
      <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit. Quia pariatur laudantium deserunt minima delectus illum dolor, nesciunt sit iure, debitis eligendi blanditiis, tempore quidem cupiditate quaerat incidunt sapiente aliquam? Debitis!</p>
      <a class="btn" href="#">Find Out More</a>
    </aside>
  </div>
  
  <div class="map-item map-item2">
    <a class="marker marker2" href="#marker2">2</a>

    <aside id="marker2" class="map-popup">
      <h3 class="popup-title">Popup Title</h3>
      <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit. Quia pariatur laudantium deserunt minima delectus illum dolor, nesciunt sit iure, debitis eligendi blanditiis, tempore quidem cupiditate quaerat incidunt sapiente aliquam? Debitis!</p>
      <a class="btn" href="#">Find Out More</a>
    </aside>
  </div>
  
  <img src="https://unsplash.it/800/480/?image=1082" alt="">
</div>
body {
  font-family: 
    -apple-system, BlinkMacSystemFont, 
    "Segoe UI", "Roboto", "Oxygen", "Ubuntu", "Cantarell", "Fira Sans", "Droid Sans", 
    "Helvetica Neue", sans-serif;
  font-size: 100%;
  line-height: 1.5;
}

img {
  max-width: 100%;
  height: auto;
}

.map {
  position: relative;
  max-width: 1100px;
  margin: auto;
  background-color: #ccc;
}
.map img {
  display: block;
  width: 100%;
}

.map-popup {
  position: absolute;
  left: 50%;
  top: 50%;
  z-index: 99;
  width: 60%;
  padding: 2rem;
  background-color: #fff;
  transition: all 300ms ease-in;
  transform: translate(-50%,-50%);
  box-shadow: 0 0 24px rgba(0,0,0,0.22);
  opacity: 0;
  visibility: hidden;
}

.map-popup > *:first-child { margin-top: 0; }
.map-popup > *:last-child { margin-bottom: 0; }

.map-popup.open {
  opacity: 1;
  visibility: visible;
}

.marker {
  position: absolute;
  z-index: 1;
  display: inline-block;
  width: 36px;
  height: 36px;
  color: #fff;
  line-height: 36px;
  text-align: center;
  text-decoration: none;
  border-radius: 50%;
  background-color: tomato;
  transition: all 300ms;
}

.marker1 {
  top: 30%;
  left: 20%;
}
.marker2 {
  top: 50%;
  left: 64%;
}

@media only screen and (min-width:48em) {
  .map-item {
    position: absolute;
    width: 36px;
    height: 36px;
    }
    .map-item .marker {
      top: auto;
      left: auto;
    }
  
  .map-item1 {
    top: 30%;
    left: 20%;
  }
  .map-item2 {
    top: 50%;
    left: 64%;
  }
  
  .map-popup {
    position: absolute;
    left: 58px;
    width: 280px;
    transform: translateY(-50%);
  }
  .map-popup:before {
    content: "";
    position: absolute;
    top: 50%;
    left: -16px;
    margin-top: -16px;
    width: 0;
    height: 0;
    border-style: solid;
    border-width: 16px 16px 16px 0;
    border-color: transparent #fff transparent transparent;
  }
  
  .map-popup.edge {
    left: auto;
    right: calc(100% + 24px);
  }
  .map-popup.edge:before {
    left: auto;
    right: -16px;
    border-width: 16px 0 16px 16px;
    border-color: transparent transparent transparent #fff;
  }
}
jQuery(function($) {
  var pop = $('.map-popup');
  pop.click(function(e) {
    e.stopPropagation();
  });
  
  $('a.marker').click(function(e) {
    e.preventDefault();
    e.stopPropagation();
    $(this).next('.map-popup').toggleClass('open');
    $(this).parent().siblings().children('.map-popup').removeClass('open');
  });
  
  $(document).click(function() {
    pop.removeClass('open');
  });
  
  pop.each(function() {
    var w = $(window).outerWidth(),
        edge = Math.round( ($(this).offset().left) + ($(this).outerWidth()) );
    if( w < edge ) {
      $(this).addClass('edge');
    }
  });
});

External CSS

This Pen doesn't use any external CSS resources.

External JavaScript

  1. https://cdnjs.cloudflare.com/ajax/libs/jquery/3.1.1/jquery.min.js