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Here you can Sed posuere consectetur est at lobortis. Donec ullamcorper nulla non metus auctor fringilla. Maecenas sed diam eget risus varius blandit sit amet non magna. Donec id elit non mi porta gravida at eget metus. Praesent commodo cursus magna, vel scelerisque nisl consectetur et.

HTML

            
              .container--outer
  .description
    h1 DNA Mutation Demo
    .instructions Drag and drop DNA to see how changes in the DNA sequence affect the resulting mRNA and amino acids.
  #app
            
          
!

CSS

            
              $dna-base: #bdc3c7;
$rna-base: #7f8c8d;
$a: #1abc9c;
$t: #2980b9;
$u: #f1c40f;
$g: #9b59b6;
$c: #e74c3c;
$time: 250ms;

.container--outer {
  align-items: center;
  display: flex;
  justify-content: space-around;
  padding: 1.5em;
}

.container--inner:not(:last-child) {
  margin-right: 6em;
}

.instructions {
  max-width: 500px;
}

.diagram {
  display: flex;
  justify-content: center;
  
  h2 {
    margin-bottom: 2em;
  }
  
  ul {
    list-style-type: none;
    padding: 0;
  }
  
  li {
    margin: 1em;
    padding: 0;
  }
}

.nucleotide--draggable {
  cursor: grab;
  
  &:active {
    cursor: grabbing;
  }
}

.dna, .rna {
  position: relative;
  
  &:before {
    background: $dna-base;
    border-top: 2px solid darken($dna-base, 15%);
    border-left: 2px solid darken($dna-base, 15%);
    content: ' ';
    height: 100%;
    left: .5em;
    position: absolute;
    transform: rotate(-25deg) skew(-25deg);
    transition: all $time;
    z-index: 0;
    width: 1em;
  }  
  
  li {
    line-height: 2em;
    margin: 0 1em;
    padding: .5em 0;
    position: relative;
    text-align: center;
    z-index: 200;
    
    div {
      height: 2em;
      width: 2em;
      z-index: 100;
    }
  }
  
}

.a { background: $a; }
.t { background: $t; }
.u { background: $u; }
.c { background: $c; }
.g { background: $g; }

.rna {
  &:before {
    background: $rna-base;
    border-top: 2px solid darken($rna-base, 15%);
    border-left: 2px solid darken($rna-base, 15%);
  }
}

.amino-acid {
  background: radial-gradient(circle at 2em 2em, pink, darken(pink, 50%));
  border-radius: 8em;
  height: 8em;
  line-height: 8em;
  margin-bottom: .5em;
  position: relative;
  text-align: center;
  width: 8em;
  
  &:before {
    border: 1px solid black;
    content: '';
    left: -2em;
    height: 0px;
    position: absolute;
    top: 50%;
    width: 1em;
  }
  
  &:after {
    border-bottom: 2px solid black;
    border-right: 2px solid black;
    border-top: 2px solid black;
    content: '';
    height: 8em;
    left: -3em;
    position: absolute;
    width: 1em;
  }
}

.amino-acid-list {
  margin-top: 3.5rem; 
}

.active-strand {
  &:before {
    background: darken($dna-base, 25%);
  }
}

.placeholder {
  height: 2em;
  position: relative;
  
  &:before {
    background: rgb(255,240,120);
    content: '';
    height: 2em;
    left: 0;
    position: absolute;
    top: .5em;
    width: 2em;
  }
}
            
          
!

JS

            
              class DNAUtils {
  static _transcriptionLookup = {
    'a': 'u',
    't': 'a',
    'c': 'g',
    'g': 'c',
  };

  static _nucleotideToNumberLookup = {
    'a': 60,
    'c': 120,
    'u': 180,
    'g': 240,
  };

  static _codonToAminoAcidLookup = {
    'uuu': 'Phenylalanine',
    'uuc': 'Phenylalanine',
    'uua': 'Leucine',
    'uug': 'Leucine',
    'cuu': 'Leucine',
    'cuc': 'Leucine',
    'cua': 'Leucine',
    'cug': 'Leucine',
    'auu': 'Isolecine',
    'auc': 'Isolecine',
    'aua': 'Isolecine',
    'aug': 'Methionine',
    'guu': 'Valine',
    'guc': 'Valine',
    'gua': 'Valine',
    'gug': 'Valine',
    'ucu': 'Serine',
    'ucc': 'Serine',
    'uca': 'Serine',
    'ucg': 'Serine',
    'ccu': 'Proline',
    'ccc': 'Proline',
    'cca': 'Proline',
    'ccg': 'Proline',
    'acu': 'Threonine',
    'acc': 'Threonine',
    'aca': 'Threonine',
    'acg': 'Threonine',
    'gcu': 'Alanine',
    'gcc': 'Alanine',
    'gca': 'Alanine',
    'gcg': 'Alanine',
    'uau': 'Tyrosine',
    'uac': 'Tyrosine',
    'uaa': 'Stop',
    'uag': 'Stop',
    'cau': 'Histidine',
    'cac': 'Histidine',
    'caa': 'Glutamine',
    'cag': 'Glutamine',
    'aau': 'Asparagine',
    'aac': 'Asparagine',
    'aaa': 'Lysine',
    'aag': 'Lysine',
    'gau': 'Aspartic acid',
    'gac': 'Aspartic acid',
    'gaa': 'Glutamic acid',
    'gag': 'Glutamic acid',
    'ugu': 'Cysteine',
    'ugc': 'Cysteine',
    'uga': 'Stop',
    'ugg': 'Tryptophan',
    'cgu': 'Arginine',
    'cgc': 'Arginine',
    'cga': 'Arginine',
    'cgg': 'Arginine',
    'agu': 'Serine',
    'agc': 'Serine',
    'aga': 'Arginine',
    'agg': 'Arginine',
    'ggu': 'Glycine',
    'ggc': 'Glycine',
    'gga': 'Glycine',
    'ggg': 'Glycine',
  }

  static codonToAminoAcid(codon) {
    return this._codonToAminoAcidLookup[codon.join('')];
  }

  static codonToRGB(codon) {
    return codon.map(nucleotide => this._nucleotideToNumberLookup[nucleotide]);
  }

  static chunkDnaIntoCodons(dna) {
    // would use lodash chunk in real life
    return dna.reduce((a, b, c) => {
        if (c % 3 == 0  && c !== 0) {
          a.push([]);
        };
        a[a.length - 1].push(b);
        return a;
      }, [[]])
      .filter(function(codon) { 
        return codon.length === 3;
      });
  }
  
  static transcribeSingleNucleotide(nucleotide) {
    return this._transcriptionLookup[nucleotide];
  }
  
  static transcribeAllNucleotides(nucleotides) {
    return nucleotides.map(nucleotide => this.transcribeSingleNucleotide(nucleotide));
  }
}

class StyleUtil {
  static darkenRgb(rgb, value) {
    if (!Array.isArray(rgb) || !Number.isInteger(value)) return;
    
    return rgb.map(color => color -= value);
  }
  
  static rgbArrayToCssString(rgb) {
    return `rgb(${rgb[0]}, ${rgb[1]}, ${rgb[2]})`;
  }
  
  static circleGradient(fromColor, toColor, size) {
    return `radial-gradient(circle at ${size} ${size}, ${fromColor}, ${toColor})`
  }
}

class MutationSimulator extends React.Component {
	constructor(props) {
		super(props);
    const { dna } = props;
    
		this.state = {
      dna,
      rna: DNAUtils.transcribeAllNucleotides(dna),
    };
	}

	render() {
    const rna = DNAUtils.transcribeAllNucleotides(this.state.dna);
    const aminoAcids = DNAUtils.chunkDnaIntoCodons(rna)
      .map((codon, i) => {
        return (
          <li key={`aminoAcid${i}`}>
            <AminoAcid codon={codon}/>
          </li>
        );
      });

    return (
      <div className="diagram">
        <div className="container--inner dna-container">
          <h2>DNA</h2>
          <Strand
            callback={this.updateNucleotides.bind(this)}
            canDrag={true}
            className='dna'
            nucleotides={this.state.dna} />
        </div>
        <div className="container--inner rna-container">
          <h2>mRNA</h2>
          <Strand
            canDrag={false}
            className="rna"
            nucleotides={this.state.rna} />
        </div>
        <div className="container--inner amino-acid-container">
          <h2>Amino Acids</h2>
          <ul className="amino-acid-list">
            {aminoAcids}
          </ul>
        </div>
      </div>
  	);
 	}

  updateNucleotides(nucleotides) {
    this.setState({
      dna: nucleotides,
      rna: DNAUtils.transcribeAllNucleotides(nucleotides)
    });
  }
}

class Strand extends React.Component {
  constructor(props) {
    super(props);
    
    this.dragged = null;
    this.placeholder = document.createElement('li');
    this.placeholder.classList.add('placeholder');
    this.state = { activeDragging: false };
  }

  _dragEnd(evt) {
    this.setState({ activeDragging: false });
    this.dragged.style.display = 'block';
    
    try {
      this.dragged.parentNode.removeChild(this.placeholder);
    } catch(e) {
      // do nothing if dropped outside target area
    }
    
    const data = this.props.nucleotides;
    const from = Number(this.dragged.dataset.id);
    let to = Number(this.over.dataset.id);
    
    if (from < to) to--;
    data.splice(to, 0, data.splice(from, 1)[0]);
    this.props.callback(data);
  }

  _dragOver(evt) {
    if (evt.target.classList.contains('dna-nucleotide')) {
      evt.preventDefault();
      try {
        this.dragged.style.display = 'none';
      } catch(e) {
        // do nothing if dragged outside target area
      }
      if (evt.target.className === 'placeholder') {
        return;
      }
      this.over = evt.target;
      evt.target.parentNode.insertBefore(this.placeholder, evt.target);
    }
  }

  _dragStart(evt) {
    this.setState({ activeDragging: true });
    this.dragged = evt.currentTarget;
    evt.dataTransfer.effectAllowed = 'move';
    evt.dataTransfer.setData('text/html', this.dragged);
  }

  render() {
    let activeClass = '';
    let dragAttributes = {};
    let nucleotides;

    if (this.props.canDrag) {
      dragAttributes = {
        draggable: true,
        onDragEnd: this._dragEnd.bind(this),
        onDragStart: this._dragStart.bind(this)
      };
    }

    if (this.state.activeDragging) {
      activeClass = 'active-strand';
    }

    nucleotides = this.props.nucleotides.map((nucleotide, i) => {
      return (
        <Nucleotide
          baseClassName={this.props.className}
          canDrag={this.props.canDrag}
          dragAttributes={dragAttributes}
          index={i}
          key={`${this.props.className}-nucleotide-${i}`}
          nucleotide={nucleotide}
        />
      );
    });

    return (
      <ul
        className={`${this.props.className} ${activeClass}`}
        onDragOver={this._dragOver.bind(this)}>
        {nucleotides}
      </ul>
    );
  }
}

Strand.propTypes = {
  callback: React.PropTypes.func,
  canDrag: React.PropTypes.bool,
  className: React.PropTypes.string.isRequired,
  nucleotides: React.PropTypes.array.isRequired
};
Strand.defaultProps = {
  canDrag: false
}

class Nucleotide extends React.Component {
  render() {
    const { baseClassName, canDrag, dragAttributes, index, nucleotide } = this.props;
    return (
      <li
        className={`${baseClassName}-nucleotide`}
        data-id={index}
        key={`${baseClassName}${nucleotide}${index}`}
        {...dragAttributes}>
        <div className={`nucleotide ${canDrag ? 'nucleotide--draggable' : ''} ${nucleotide}`}>                     {nucleotide}
        </div>
      </li> 
    );
  }
}

Nucleotide.propTypes = {
  canDrag: React.PropTypes.bool,
  baseClassName: React.PropTypes.string,
  dragAttributes: React.PropTypes.object,
  index: React.PropTypes.number,
  nucleotide: React.PropTypes.string,
}

class AminoAcid extends React.Component {
  getBackgroundColor(codon) {
    const codonRgb = DNAUtils.codonToRGB(codon);
    const darkenedRgb = StyleUtil.darkenRgb(codonRgb, 60);
    const colorString = StyleUtil.rgbArrayToCssString(codonRgb);
    const darkenedColorString = StyleUtil.rgbArrayToCssString(darkenedRgb);

    return StyleUtil.circleGradient(colorString, darkenedColorString, '2em');
  }

  render() {
    const styles = { background: this.getBackgroundColor(this.props.codon) };
    const aminoAcidName = DNAUtils.codonToAminoAcid(this.props.codon) || 'Other';

    return (
      <div className="amino-acid" style={styles}>
        {aminoAcidName}
      </div>
    );
  }
}

AminoAcid.propTypes = {
  codon: React.PropTypes.array.isRequired
}

ReactDOM.render(
	<MutationSimulator dna={['a', 'c', 'g', 't', 'a',
            'c', 't', 'g', 'g', 'c', 'c']}/>,
  document.getElementById('app')
);
            
          
!
999px

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