<div class="container">
  <div class="item">Item 1</div>
  <div class="item align-me">Item 2</div>
  <div class="item">Item 3</div>
</div>

.container {
  display: flex;
  align-items: center; /* Aligns all items to the center of the cross-axis */
  height: 200px;
  border: 2px dashed #aaa;
}

.item {
  width: 50px;
  height: 50px;
  background-color: lightblue;
  margin: 5px;
  display: flex;
  justify-content: center;
  align-items: center;
}

.align-me {
  align-self: flex-end; /* Overrides container's align-items property */
  background-color: lightcoral;
}