<iframe src="/" id="iframe"></iframe>

<script>
  let oldDoc = iframe.contentDocument;

  // every 100 ms check if the document is the new one
  let timer = setInterval(() => {
    let newDoc = iframe.contentDocument;
    if (newDoc == oldDoc) return;

    alert("New document is here!");

    clearInterval(timer); // cancel setInterval, don't need it any more
  }, 100);
</script>