<style>
  span { font-weight: bold }
</style>

<user-card>
  <div slot="username"><span>John Smith</span></div>
</user-card>

<script>
customElements.define('user-card', class extends HTMLElement {
  connectedCallback() {
    this.attachShadow({mode: 'open'});
    this.shadowRoot.innerHTML = `
      <style>
      span { background: red; }
      </style>
      Name: <slot name="username"></slot>
    `;
  }
});
</script>